![]() To explore this, we used a large cohort of healthy, first-time marathon runners investigated before training initiation and after completion of the London Marathon. We hypothesized that age-related aortic stiffening in health would be reversible with real-world exercise training. Because the aorta has varying tissue composition, local distensibility measured at discrete levels may facilitate the detection of regional influences. This is a stronger prognostic marker, and is more closely associated with the natural aging process ( 13–15). Using cardiovascular magnetic resonance (CMR), it is now possible to assess local arterial stiffness by distensibility in the aorta rather than peripheral vessels. The dose of exercise needed to preserve or even rejuvenate the central (aortic) arterial system in a real-world setting is not known. Cross-sectional studies have shown that lifelong athletes possess more distensible peripheral arteries ( 10), and relatively brief (<3 months) supervised aerobic exercise interventions benefit brachial blood pressure (BP) and peripheral artery stiffness ( 11, 12). Mass participation running is an increasingly popular form of nonprescribed exercise, with 18 million finishers in the United States in 2018 ( 9). One potential beneficial strategy is regular aerobic exercise ( 8). Antihypertensive agents can modify arterial stiffness once established in disease, but more cardiovascular events occur in individuals without diagnosed hypertension ( 5), providing an opportunity for early lifestyle modification in health ( 6, 7). Such changes in hemodynamics are associated with dementia and cardiovascular and kidney disease ( 1–3), even in the absence of atherosclerosis ( 4), suggesting that age-related arterial stiffening is detrimental to health. The aorta buffers pulsatile stroke volume and translates this to steady peripheral flow therefore, progressive stiffening increases pulse pressure (PP) and ventricular afterload. In large arteries, advancing age is associated with biochemical and histological changes that result in vessel stiffening. Performs all other duties as needed or directed.Aging is a major risk factor for cardiovascular disease beyond simple cumulative conventional risk factor exposure. ![]() Participates in and successfully completes Mandatory Education.Participates in departmental and/or interdepartmental quality improvement activities.Demonstrates a commitment toward meeting and exceeding the needs of our customers and consistently adheres to our customer service standards.Demonstrates an understanding of job description, performance expectations, and competency assessment.Maintains courteous and effective interactions with colleagues and patients, utilizes tools provided.Complies with behavioral expectations of the department and Lahey Health.Complies with all Lahey Health Policies.Incorporates Lahey Health Guiding Principles and Mission Statement into daily activities.Actively pursues opportunities to become multi-skilled to serve a more diverse role in the organization.Actively seeks opportunities for self-improvement through self-awareness and feedback.The actual functions may differ based on the department and/or the project involved.Providing back up phone coverage, answering the phone in a polite and courteous manner, directing calls as appropriate and answering basic, repetitive questions.Packing files and documenting contents for long term storage.Cleaning out and organizing storage areas and filing cabinets.Inputting specific data in limited fields.Collecting specific information from patients and others.Checking patients out and scheduling appointments.Referencing data from a database or computer system and documenting and/or communicating as appropriate.
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